The recommended daily dose of TARCEVA for NSCLC is 150 mg taken on an empty stomach, i.e., at least one hour before or two hours after the ingestion of food. Treatment should continue until disease progression or unacceptable toxicity occurs.

How do you dissolve erlotinib?

For maximum solubility in aqueous buffers, erlotinib should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Erlotinib has a solubility of approximately 0.1 mg/ml in a 1:9 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

What is difference between erlotinib and gefitinib?

Gefitinib has been approved only for EGFR mutation bearing patients regardless the line of treatment, while erlotinib is also indicated in patients without EGFR mutation who undergo second- or third-line treatment.

Can Tarceva be cut in half?

Erlotinib is taken by mouth, in tablet form, once a day. It is usually taken on an empty stomach, at least 1 hour before or 2 hours after eating a meal or snack. Take erlotinib at around the same time every day. Take the tablet whole, do not break, crush or chew.

What class drug is erlotinib?

Erlotinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

What is targettarceva used to treat?

TARCEVA is a kinase inhibitor indicated for: • Maintenance treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose disease has not progressed after four cycles of platinum-based first-line chemotherapy.

What is the most common adverse reaction to Tarceva?

The most common adverse reactions with TARCEVA are rash and diarrhea usually with onset during the first month of treatment. The incidences of rash and diarrhea from clinical studies of TARCEVA for the treatment of NSCLC and pancreatic cancer were 70% for rash and 42% for diarrhea.

What is the recommended dose of Tarceva for NSCLC?

2.2 Recommended Dose – NSCLC The recommended daily dose of TARCEVA for NSCLC is 150 mg taken on an empty stomach, i.e., at least one hour before or two hours after the ingestion of food. Treatment should continue until disease progression or unacceptable toxicity occurs.