IL-12p40 (p40) is a subunit of the IL-12 family of cytokines, which associates with the p35 subunit to form IL-12p70 (IL-12) and with the p19 subunit to form IL-23. IL-12 is a well-known inducer of the Th1 response, and polymorphisms of the IL-23 receptor are negatively associated with the development of IBD.

What is the function of interleukin 12?

Interleukin (IL)-12 was cloned on the basis of its ability to activate natural killer (NK) cells and promote the development of cytolytic T cells. With further understanding of its activities, IL-12 has emerged as an important cytokine, affecting both immune and hematologic functions.

What induces IL-12?

Interleukin 12 (IL-12) is produced by activated antigen-presenting cells (dendritic cells, macrophages). It promotes the development of Th1 responses and is a powerful inducer of IFNγ production by T and NK cells.

What is il12p40?

Subunit beta of interleukin 12 (also known as IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, or interleukin-12 subunit p40) is a protein that in humans is encoded by the IL12B gene. IL-12B is a common subunit of interleukin 12 and Interleukin 23.

Is IL-12 anti-inflammatory?

IL-12 can aid in the activation and regulation of several cytotoxic immune cells including macrophages, natural killer cells, and T cells, thus making it a ‘pro-inflammatory cytokine’.

Is IL-12 anti inflammatory?

Is IL 12 anti inflammatory?

What do interleukins do in the immune system?

Interleukins regulate cell growth, differentiation, and motility. They are particularly important in stimulating immune responses, such as inflammation. Interleukins are a subset of a larger group of cellular messenger molecules called cytokines, which are modulators of cellular behaviour.

What are IL-12 and IL-23?

Interleukin (IL)-12 and IL-23 are important cytokines which are involved in the adaptive immune responses and their common pathway has been found to play a determinant role in the induction of inflammation.

What is human Interleukin-12 p40 (Hu IL-12p40) Elisa?

The Human Interleukin-12 p40 (Hu IL-12 p40) ELISA quantitates Hu IL-12 p40 in human serum, plasma, buffered solution, or cell culture medium. The assay will exclusively recognize both natural and recombinant Hu IL-12 p40.

Is Interleukin 12 P40 associated with atopic asthma?

The promoter gene polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. Interleukin-12 p40 also serves as a subunit of Interleukin 23. ^ “Human PubMed Reference:”.

Is Interleukin 12p40 (IL-12p40) a functional cytokine?

IL-12p40 is known as a component of the bioactive cytokines interleukin (IL)-12 and IL-23 but it is not widely recognized as having intrinsic functional activity. Recent publications have altered this perception and support an independent role for IL-12p40. IL-12p40 is induced in excess over the oth …

How does the IL-12 p40 assay work?

The assay will exclusively recognize both natural and recombinant Hu IL-12 p40. The Human IL-12 p40 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate.