Aspirin causes several different effects in the body, mainly the reduction of inflammation, analgesia (relief of pain), the prevention of clotting, and the reduction of fever. Much of this is believed to be due to decreased production of prostaglandins and TXA2.

What is the expected pharmacological action of aspirin?

Aspirin is known as a salicylate and a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking a certain natural substance in your body to reduce pain and swelling.

What is the process of aspirin?

Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride. The molecular weight of aspirin is 180.16g/mol. Aspirin is an oral non-steroidal anti-inflammatory drug (NSAID) that is rapidly absorbed from the stomach and the small intestine.

What is the action of aspirin as an antiplatelet?

Mechanism of action: Aspirin (acetylsalicylic acid) irreversibly inhibits prostaglandin H synthase (cyclooxygenase-1) in platelets and megakaryocytes, and thereby blocks the formation of thromboxane A2 (TXA2; a potent vasoconstrictor and platelet aggregant).

What is the mechanism of action of aspirin in preventing clotting?

The primary established effect of aspirin on hemostasis is to impair platelet aggregation via inhibition of platelet thromboxane A2 synthesis, thus reducing thrombus formation on the surface of the damaged arterial wall.

How does aspirin act as an analgesic?

These results suggest that aspirin has two analgesic effects on the inflammatory pain; one may be the inhibition of prostaglandin biosynthesis by acetylation of cyclo-oxygenase, and the other may be an action due to salicylic acid. Salicylic acid may produce its analgesic action mainly via a central mechanism.

What are the properties of aspirin?

Aspirin is an orally administered non-steroidal antiinflammatory agent. Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. This agent exhibits analgesic, antipyretic, and anticoagulant properties.

How does aspirin block normal prostaglandin function?

Anti-inflammatory drugs, such as aspirin and ibuprofen, work by blocking the action of the cyclooxygenase enzymes and so reduce prostaglandin levels. This is how these drugs work to relieve the symptoms of inflammation.

How NSAIDs block the action of prostaglandin?

NSAIDs generally work by blocking the production of prostaglandins (PGs) through the inhibition of two cyclooxygenase enzymes. PGs are key factors in many cellular processes, such as gastrointestinal cytoprotection, hemostasis and thrombosis, inflammation, renal hemodynamics, turnover of cartilage, and angiogenesis.

How does aspirin affect platelet aggregation?

Aspirin acts on platelets by acetylating the cyclooxygenase enzyme at position serine 529, resulting in reduced formation of cyclic endoperoxides (prostaglandin G2 and prostaglandin H2) and thromboxane from arachidonic acid.

What are the different uses of aspirin?

Aspirin is used to reduce fever and relieve mild to moderate pain from conditions such as muscle aches, toothaches, common cold, and headaches. It may also be used to reduce pain and swelling in conditions such as arthritis. Aspirin is known as a salicylate and a nonsteroidal anti-inflammatory drug (NSAID).

What are other uses of aspirin?

Aspirin, or acetylsalicylic acid (ASA), is commonly used as a pain reliever for minor aches and pains and to reduce fever. It is also an anti-inflammatory drug and can be used as a blood thinner. People with a high risk of blood clots, stroke, and heart attack can use aspirin long-term in low doses.

What is the formula for aspirin?

Aspirin Formula. Aspirin, which the chemical name acetylsalicylic acid (ASA), is medication extensively used around the world as an anti-inflammatory and anti-pyretic. Formula and structure: The acetylsalicylic acid chemical formula is C9H8O4 and the extended formula is CH3COOC6H4COOH.

What is the mechanism of aspirin?

Aspirin relieves pain by inhibiting production of chemicals called prostaglandins, aspirin works to diminish the body’s response to a chain of chemical processes that eventually leads to pain. This mechanism of action works on a cellular level.