Hyperdiploid-myeloma is associated with male sex, kappa immunoglobulin subtype, symptomatic bone disease and better survival compared to nonhyperdiploid-MM (median overall survival 48 vs 35 months, log-rank P=0.023), despite similar response to treatment.

Which karyotype is a molecular marker of good prognosis in ALL children?

Children with hyperdiploid karyotype ALL generally have favorable prognosis, and the cure rate is over 90%; particularly, chromosomes 4, 10, and 17 are trisomy at the same time.

What causes Hyperdiploidy?

One of the root questions in this subtype of ALL is how this hyperdiploidy arise? (i) Is it by mitotic events when a haploid cell is produced and subsequent mitosis and loss of chromosome leads to hyperdiploidy[3,15] or a single mitotic event producing hyperdiploid (tetraploid) karyotype then loss of chromosomes in …

How does Hyperdiploidy happen?

The great majority of cases of hyperdiploid ALL appear to be the result of the simultaneous gain of extra chromosomes in a single abnormal cell division.

Which cytogenetic abnormality is associated with an excellent prognosis in children with B cell acute lymphoblastic leukemia all?

The t(12;21)(p13;q22) is a cryptic abnormality observed in 25% of children with B-lineage acute lymphoblastic leukemia (ALL), associated with a favorable prognosis.

What is BCR ABL gene rearrangement?

The BCR-ABL mutation happens when pieces of BCR and ABL genes break off and switch places. The piece of chromosome 9 that breaks off includes part of the ABL gene. When this piece moves over to chromosome 22, part of the ABL gene attaches to the BCR gene. The merged gene is called the BCR-ABL fusion gene.

What is the prognosis of TEL-AML1 positive for acute myeloid leukemia?

TEL-AML1 positivity predicted a favorable short-term outcome; long-term results are unknown. Screening for TEL-AML1 should become routine at relapse diagnosis and might be used for therapy stratification in future trials.

Is TEL-AML1 fusion incidence lower in patients with all relapse?

The resulting fusion transcript, termed TEL-AML1, has been associated with an excellent prognosis at initial ALL diagnosis. Hence, we postulated that the incidence of TEL-AML1 fusion should be lower in patients with ALL relapse.

Is TEL-AML1 expression related to relapsed childhood all in children?

Hence, we postulated that the incidence of TEL-AML1 fusion should be lower in patients with ALL relapse. To address this assumption and to investigate the prognostic significance of TEL-AML1 expression in relapsed childhood ALL, bone marrow samples of 146 children were analyzed by reverse-transcriptase (RT)-polymerase chain reaction (PCR).